What makes us different
We feature only brands we vet, bought direct from their makers, and our protocols, opening with our full site, add honest evidence grades, studied doses, combining checks and timed refills.
In plain words
- We only feature brands we have checked.
- Our protocols open with our full site. Each product will show how strong the science is, even when it's weak.
- Each will show the dose the studies used next to what the label gives.
- Plans come in three steps, so you can start small.
- We check how products mix, so nothing doubles up or goes over the daily limit.
An approved-brand standard
We start from a short list of brands, judged on six things: active forms named on the label, every dose printed plainly, certificates of analysis from accredited outside labs, clean inactive ingredients, manufacturing under the FDA's good manufacturing practice rules for supplements [1], and the last test, whether we would trust it enough to take it ourselves. We re-check them, and a brand that stops meeting them comes off the list. When a premium brand makes the right product, it gets our pick; value brands appear as alternatives.
Every product also comes through Fullscript, which says it sources directly from the brands, vets every brand in its catalog with its medical and quality teams, and has products tested for potency and purity [2][3]. Those are Fullscript's checks, layered on top of ours.
Honest evidence grades
Every product in our protocols carries a plain evidence label: Strong, Moderate, Limited or Early evidence. Two labels describe a role rather than a trial result: Established biochemistry, and Essential nutrient function for a vitamin or mineral doing a job the body can't do without. When no trial fits, it says Not graded.
We grade honestly even when the honest grade is Limited, because a grade is only useful if it can be low. Grades describe normal structure and function at the form and dose studied, never disease. Federal guidance already expects health claims to rest on competent and reliable scientific evidence [4]; we show you where that evidence stands.
Studied doses, matched to labels
For each part of a protocol we choose the form the research used and show the amount the studies used, or the label serving where no study dose exists. Next to it we show what the product's label actually gives, and whether the two match. Where they don't, we say so instead of hiding it.
No hidden doses: where a product uses a proprietary blend, we name it as a blend and never claim a studied dose for an amount the blend hides.
Three tiers: Start here, Full and Go deep
Every protocol has three tiers. Start here is the few products you begin with. Full adds the rest of the core and the advanced picks. Go deep adds cutting-edge options for people who want everything the evidence supports. Each tier comes with a day plan, so you know what to take at breakfast, dinner or bedtime, and a staged start, so new products begin a few days apart.
We keep the day simple on purpose. In a review of 76 studies of medicine-taking, people took 79% of their doses on a once-a-day schedule but only 51% on a four-times-a-day schedule [5].
Safe-combining checks across protocols
People rarely follow just one plan, so our system checks protocols together. It totals each nutrient across everything you follow and checks it against the adult upper limits, such as 4,000 IU of vitamin D and 350 mg of supplemental magnesium a day [6].
Take-once rules make sure a shared ingredient is taken, and counted, once. Don't-combine rules cover pairs and timings that don't belong together. And each product is tagged with how it works, so two products doing the same job don't land in one day by accident.
Refills that match each bottle
Each product in a protocol records how long its bottle lasts, so its refill can be set to match. A bottle that lasts 45 days and one that lasts 30 shouldn't share a refill date. Fullscript's auto-refill lets you set the schedule and sends reminders a week and a day before each refill ships [7].
Plain words first, deep science second
Every page opens with In plain words: a few short lines anyone can follow. The deep science sits underneath for anyone who wants the mechanisms, the trials and their limits, with each source next to the sentence it supports.
Custom plans and coaching
If a ready-made protocol doesn't fit, a person on our team can build one around your goal and routine, with the same checks, and deliver it as a plan in our store. Coaching adds check-ins while you run it. It's wellness education, not medical care; our coaching and custom plans page has the details.
No paid placements
No brand pays to be listed, ranked or picked by us, and we take no affiliate commissions. Picks come from the evidence and our brand standard.
When you can see it
Our store is open now. The protocols, evidence grades, day plans and refill timing described here open with our full site, coming soon.
Our supplement store is open
Shop the brands we trust through our Fullscript dispensary.
Shop our storeShips to US addresses only.
Common questions
Are your protocols live yet?
Our store is open now. Protocol pages, with their grades, day plans and refill timing, open with our full site. Until then, we can build a custom plan for you.
Why do some products get a low grade?
Because that's where the research stands. A low grade doesn't mean a product is poor quality; it means the human trials are few, small or mixed. We'd rather tell you than dress it up.
Do brands pay you to be listed?
No. No brand pays to be listed, ranked or picked.
Do your doses always match the studies?
Not always, and we show you when they don't. Each product lists the amount the studies used next to what its label gives.
References
- 1.Code of Federal Regulations. 21 CFR Part 111: Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements. Government source
- 2.Fullscript. Supplement quality for patients (sourcing, testing and brand vetting). Fullscript
- 3.Fullscript. High-quality supplement program. Fullscript
- 4.Federal Trade Commission (2022). Health Products Compliance Guidance. FTC
- 5.Claxton AJ, Cramer J, Pierce C (2001). A systematic review of the associations between dose regimens and medication compliance. Clinical Therapeutics 23(8):1296-1310. DOI
- 6.Institute of Medicine (2011). Dietary Reference Intakes for Calcium and Vitamin D. Summary tables: Tolerable Upper Intake Levels. National Academies Press. Journal page
- 7.Fullscript Support (2026). How auto refills work with Fullscript. Fullscript
